abstract：:Bone marrow transplantation is currently used to treat a variety of life-threatening diseases. Its applications could be expanded if the risks of graft-versus-host disease (GVHD), a complex pathologic disease, could be reduced. Immunotoxins may provide a means to control drug refractory GVHD. This article will discuss...

journal_title：Seminars in cancer biology

authors： Vallera DA

更新日期：1996-04-01 00:00:00

abstract：:The treatment of cancer with tumor vaccines has been a goal of physicians and scientists ever since effective immunization against infectious disease with vaccines was developed. In the past, major tumor antigens had not been molecularly characterized. Recent advances are, however, beginning to define potential molecu...

journal_title：Seminars in cancer biology

authors： Lewis JJ,Houghton AN

更新日期：1995-12-01 00:00:00

abstract：:The molecular cloning of protein phosphatase 2A subunits from Drosophila has provided insights into the role this enzyme plays in developmental processes and in cell cycle regulation. The trimeric holoenzyme containing the catalytic, 65-kDa and 55-kDa regulatory subunits appears to be preferentially expressed in proli...

journal_title：Seminars in cancer biology

authors： Mayer-Jaekel RE,Hemmings BA

更新日期：1995-08-01 00:00:00

abstract：:In this short review, we will give an overview of the various genes that can be activated by insertion of proviral DNA of the mouse mammary tumor virus during the formation of mammary cancer. These genes fall within three families: Wnt genes, FGF genes and Notch-related genes. We will summarize our current understandi...

journal_title：Seminars in cancer biology

authors： van Leeuwen F,Nusse R

更新日期：1995-06-01 00:00:00

abstract：:The retinoblastoma tumor suppressor gene is inactivated in retinoblastomas and a variety of other tumor types. In addition, it is one of several cellular proteins targeted by the transforming proteins of the small DNA tumor viruses. At least two other cellular proteins that are targeted by the viral transforming prote...

journal_title：Seminars in cancer biology

authors： Whyte P

更新日期：1995-04-01 00:00:00

abstract：:Viability is a fundamental determinant of all cellular functions, and regulation of cell viability is important in shaping tissue differentiation and organism development. The genes in the bcl-2 family can profoundly influence cell viability. In addition to bcl-2, cellular genes in this family include bcl-x, bax, mcl-...

journal_title：Seminars in cancer biology

authors： Craig RW

更新日期：1995-02-01 00:00:00

abstract：:Distant metastasis is the major cause for therapeutic failures in clinical oncology. Active immunotherapy of patients with low tumor burden would not only contribute to further reduction of the remaining tumor burden to subclinical levels, but it would also establish a constant state of immunity, i.e. immunological me...

journal_title：Seminars in cancer biology

authors： Gilboa E,Lyerly HK,Vieweg J,Saito S

更新日期：1994-12-01 00:00:00

abstract：:Epidemiological studies implicate steroid hormones as important factors in the development of neoplasia, and hormonal manipulation constitutes an important treatment arm in cancer therapy. Recent studies demonstrate a key role for nuclear receptor proteins in the expression of genes encoding the cytochrome P450 enzyme...

journal_title：Seminars in cancer biology

authors： Parker KL,Schimmer BP

更新日期：1994-10-01 00:00:00

abstract：:Raf-1 belongs to a family of serine/threonine protein kinases which are highly conserved through evolution in multicellular organisms. Raf-1 kinase has gained much attention due to its function as a critical shuttle enzyme that connects stimulation of growth factor receptors and protein kinase C at the cell membrane t...

journal_title：Seminars in cancer biology

authors： Magnuson NS,Beck T,Vahidi H,Hahn H,Smola U,Rapp UR

更新日期：1994-08-01 00:00:00

abstract：:While the centrality of aberrant cell proliferation in cancer was widely acknowledged long ago, it is only recently that the control of cell death has been recognized as an important target in carcinogenesis. Various lines of evidence now suggest that p53 is a positive regulator of cell death, and particularly of apop...

journal_title：Seminars in cancer biology

authors： Oren M

更新日期：1994-06-01 00:00:00

abstract：:In vitro transformation of replicating myogenic cells by a variety of oncogenes is always accompanied by inhibition of the transition to the terminally differentiated state. Three main levels of interference by oncogenes may ultimately prevent transcription of skeletal muscle-specific genes. First, the transcription o...

journal_title：Seminars in cancer biology

authors： Alemà S,Tatò F

更新日期：1994-04-01 00:00:00

abstract：:The transgenic mouse has emerged as an important model system to assess the transforming potential of oncogenes in the mammary epithelium. Mammary gland-specific expression of oncogenes in transgenic mice has resulted in the induction of a variety of phenotypes ranging from benign epithelial hyperplasias to metastatic...

journal_title：Seminars in cancer biology

authors： Webster MA,Muller WJ

更新日期：1994-02-01 00:00:00

abstract：:T cell acute leukaemias involve a number of different classes of oncogenes. A group of such genes is the RBTN family located on chromosomes 11 and 12. Two members of this family, RBTN1/Ttg-1 and RBTN2/Ttg-2, are located near recurring T cell acute lymphocytic leukaemia-associated translocations. Chromosomal translocat...

journal_title：Seminars in cancer biology

authors： Sánchez-García I,Rabbitts TH

更新日期：1993-12-01 00:00:00

abstract：:Alterations in the rate and pattern of cell movement are prominent features of many human diseases, including inflammation, cardiovascular disease and cancer. The ability to regulate the interactions of cells with each other and with adhesion factors in extracellular matrices therefore offers a novel approach to the t...

journal_title：Seminars in cancer biology

authors： Humphries MJ

更新日期：1993-10-01 00:00:00

abstract：:Human bladder carcinogenesis stands as a paradigm for research on the molecular genetic mechanisms of chemical carcinogenesis. The pathogenesis of bladder cancer is multistage with a typical onset later in life. Epidemiological studies associate occupational exposure to aromatic amines with increased bladder cancer ri...

journal_title：Seminars in cancer biology

authors： Reznikoff CA,Kao C,Messing EM,Newton M,Swaminathan S

更新日期：1993-06-01 00:00:00

abstract：:The yeast Saccharomyces provides a powerful system for investigating the biological effects of ionizing radiation, and studies have identified double-strand breaks in DNA as probably of critical importance in determining lethality. These breaks are normally repaired by a recombinational mechanism, but in the absence o...

journal_title：Seminars in cancer biology

authors： Game JC

更新日期：1993-04-01 00:00:00

abstract：:Growing evidence indicates that antisense oligodeoxynucleotides can specifically inhibit gene expression thereby providing an essential tool for understanding gene function and the potential to affect abnormal cell proliferation. Because oncogene activation is intimately involved in tumour initiation and progression, ...

journal_title：Seminars in cancer biology

authors： Calabretta B,Skorski T,Zon G

更新日期：1992-12-01 00:00:00

abstract：:Human papillomavirus (HPV)-induced skin warts are classically benign lesions. However an association between specific HPV types and skin cancer becomes obvious in epidermodysplasia verruciformis (EV). The analysis of this disease suggests that lesions infected with HPV types 5 and 8 carry a high risk of developing squ...

journal_title：Seminars in cancer biology

authors： Pfister H

更新日期：1992-10-01 00:00:00

abstract：:Angiogenesis, the growth of blood capillaries, is regulated by soluble growth factors and insoluble extracellular matrix (ECM) molecules. Soluble angiogenic mitogens act over large distances to initiate capillary growth whereas changes in ECM govern whether individual cells will grow, differentiate, or involute in res...

journal_title：Seminars in cancer biology

authors： Ingber DE

更新日期：1992-04-01 00:00:00

abstract：:Mucins are large molecular weight glycoproteins characterized by carbohydrate sugars attached via 'O-glycosidic' linkages to serine or threonine. Mucins are synthesized by a variety of epithelial tissues as membrane-bound or secreted proteins, encoded by several distinct mucin genes. Numerous alterations of mucin-asso...

journal_title：Seminars in cancer biology

authors： Ho SB,Kim YS

更新日期：1991-12-01 00:00:00

abstract：:What is the clinical significance of the expression by common human carcinomas of the Thomsen-Friedenreich (TF) antigen? Described as a terminal disaccharide which is a precursor of MN blood group antigens, it was discovered as a laboratory curiosity 60 years ago, yet its cancer-association has only been appreciated i...

journal_title：Seminars in cancer biology

authors： MacLean GD,Longenecker BM

更新日期：1991-12-01 00:00:00

abstract：:In animal models complete and permanent eradication of tumors can be achieved by adoptive transfer of tumor specific T cells, combined with interleukin 2. The most active cells are CD8+ cytotoxic T lymphocytes (CTL), which recognize peptides of 8-10 amino acids in length, bound to the antigen presenting groove of MHC ...

journal_title：Seminars in cancer biology

authors： Melief CJ,Kast WM

更新日期：1991-10-01 00:00:00

abstract：:The marginal level of clinical responses to the Chloroethylnitrosoureas (CENU, i.e. BCNU, CCNU, MeCCNU) suggests that there may exist an innate mechanism of resistance in tumors to these chemotherapeutic agents. A decade of research from many laboratories around the world has led to the identification of the mechanism...

journal_title：Seminars in cancer biology

authors： Erickson LC

更新日期：1991-08-01 00:00:00

abstract：:Intrinsic and acquired resistance to antineoplastic agents remains an important impediment to cancer therapy. Intracellular metallothioneins appear to be one factor in determining the responsiveness of malignant and normal cells to electrophilic anticancer agents. Metallothioneins are not only constitutively expressed...

journal_title：Seminars in cancer biology

authors： Lazo JS,Basu A

更新日期：1991-08-01 00:00:00

abstract：:Transfection experiments indicate that a number of genes can induce or suppress the metastatic phenotype. These genes include ten oncogenes, plasminogen activator, and three suppressor genes. The biochemical mechanism(s) whereby each of these genes alters the metastatic phenotype is poorly understood. Hypotheses conce...

journal_title：Seminars in cancer biology

authors： Steeg PS

更新日期：1991-04-01 00:00:00

abstract：:The ski oncogene is the transforming gene, v-ski, of the defective SKV avian carcinoma viruses. V-ski transformation causes increased proliferation of embryo fibroblasts and also induces a number of genes characteristic of the muscle lineage. In natural SKV isolates the 49 kDa v-ski polypeptide is expressed as a fusio...

journal_title：Seminars in cancer biology

authors： Colmenares C,Stavnezer E

更新日期：1990-12-01 00:00:00

abstract：:The growth regulatory functions of a family of structurally related polypeptides are mediated through the membrane-bound epidermal growth factor receptor molecule. This ligand family includes epidermal growth factor, transforming growth factor-alpha, amphiregulin, and polypeptides encoded by several poxviruses. The st...

journal_title：Seminars in cancer biology

authors： Todaro GJ,Rose TM,Spooner CE,Shoyab M,Plowman GD

更新日期：1990-08-01 00:00:00

abstract：:The cysteine proteinase cathepsin B has been implicated in the progression of tumors from a premalignant to a malignant state. Activity of cathepsin B has been shown to be elevated in parallel with malignancy or metastatic potential of human and rodent tumors. These increases in cathepsin B activity correspond in part...

journal_title：Seminars in cancer biology

authors： Sloane BF

更新日期：1990-04-01 00:00:00

abstract：:Cellular immediate-early genes are rapidly and transiently activated when cells are stimulated with many different growth factors. This review examines the function of a short immediate-early gene regulatory sequence, the Serum Response Element (SRE), that is sufficient for this transient transcriptional activation. T...

journal_title：Seminars in cancer biology

authors： Treisman R

更新日期：1990-02-01 00:00:00